Tony La Russa‘s doctors told him not to manage this season:

La Russa, 78, has been advised by his doctors not to manage again in 2022. He has been out since late August with a heart ailment, and after undergoing additional testing and medical procedures over the past week, it was determined he should not return.

It’s not clear if La Russa will manage the White Sox next season. By all accounts, the team has underachieved this year, which has included another season of injuries to key players.

ESPN.com

It also La Russa making odd intentional walk choices, issuing those a few times with strikes on the batter. It makes me wonder if the heart condition was causing poor blood flow which led to cognitive issues.